In her fifth year atop of Fortune’s 50 Most Powerful Women in Business List, Indra Nooyi, Chairman and CEO of PepsiCo, completed the purchase of PepsiCo’s two largest bottlers, bringing revenues to a projected $60 billion. Now she’ll have to deliver the $400 million annual cost savings she promised. Investors seem assured: The stock is up 12% since September 2009. She is followed by Irene Rosenfeld, Chairman and CEO of Kraft Food. Rosenfeld’s battle for candy maker Cadbury rankled Kraft’s largest shareholder, Warren Buffett’s Berkshire Hathaway, but analysts say the $19 billion purchase is sweet: It pushes Kraft to $48 billion in revenue and gives the food giant a bigger foothold in emerging markets like India. See the entire list here.